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つくばリポジトリ (Tulips-R) >
0 コンテンツタイプ別 (Content type) >
01 雑誌発表論文等 (Journal article, etc.) >
Schizophrenia research >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/99800
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| Title: | A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia |
| Authors: | Ohtsuki, Tsuyuka
Koga, Minori
Ishiguro, Hiroki
Horiuchi, Yasue
Arai, Makoto
Niizato, Kazuhiro
Itokawa, Masanari
Inada, Toshiya
Iwata, Nakao
Iritani, Shyuji
Ozaki, Norio
Kunugi, Hiroshi
Ujike, Hiroshi
Watanabe, Yuichiro
Someya, Toshiuki
Arinami, Tadao
石黒, 浩毅
有波, 忠雄 |
| Issue Date: | Apr-2008 |
| Publisher: | Elsevier B.V. |
| Journal Title: | Schizophrenia research |
| Volume: | 101 |
| Issue: | 1-3 |
| Start Page: | 9 |
| End Page: | 16 |
| DOI: | 10.1016/j.schres.2008.01.027 |
| PMID: | 18329248 |
| Abstract: | Introduction: Glutamate dysfunction has been implicated in the pathophysiology of schizophrenia. The metabotropic glutamate
receptors (mGluRs) are G-protein-coupled receptors. GRM7, the gene that encodes mGluR7, is expressed in many regions of the
human central nervous system. The GRM7 gene is located on human chromosome 3p26, which has been suggested by linkage
analysis to contain a susceptibility locus for schizophrenia.
Methods: We screened for mutations in all exons, exon/intron junctions, and promoter regions of the GRM7 gene in Japanese
patients with schizophrenia and evaluated associations between the detected polymorphisms and schizophrenia. We examined the
influence of one polymorphism associated with schizophrenia on the expression of GRM7 by dual-luciferase assay in transfected
cells.
Results: Twenty-five polymorphisms/mutations were detected in GRM7. Case-control analysis revealed a potential association of a
synonymous polymorphism (371T/C, rs3749380) in exon 1 with schizophrenia in our case-control study of 2293 Japanese patients
with schizophrenia and 2382 Japanese control subjects (allelic p=0.009). Dual-luciferase assay revealed suppression of transcription activity by exon 1 containing this polymorphism and a statistically significant difference in the promoter activity
between the T and C alleles.
Conclusions: Our results support the possible association of a GRM7 gene polymorphism with genetic susceptibility to
schizophrenia. |
| URI: | http://hdl.handle.net/2241/99800 |
| Rights: | © 2008 Elsevier B.V. |
| Text Version: | author |
| Appears in Collections: | Schizophrenia research
石黒 浩毅 (Ishiguro Hiroki)
有波 忠雄 (Arinami Tadao)
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