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つくばリポジトリ (Tulips-R) >
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Cancer research >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/117284
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| Title: | A Novel Transgenic Mouse Model of the Human Multiple Myeloma Chromosomal Translocation t(14;16)(q32;q23) |
| Authors: | Morito, Naoki
Yoh, Keigyou
Maeda, Atsuko
Nakano, Takako
Fujita, Akiko
Kusakabe, Manabu
Hamada, Michito
Kudo, Takashi
Yamagata, Kunihiro
Takahashi, Satoru
森戸, 直記
楊, 景堯
工藤, 崇
山縣, 邦弘
高橋, 智 |
| Issue Date: | Jan-2011 |
| Publisher: | American Association for Cancer Research |
| Journal Title: | Cancer research |
| Volume: | 71 |
| Issue: | 2 |
| Start Page: | 339 |
| End Page: | 348 |
| DOI: | 10.1158/0008-5472.CAN-10-1057 |
| PMID: | 21224354 |
| Abstract: | Multiple myeloma (MM) is a currently incurable neoplasm of terminally differentiated B cells. The translocation and/or overexpression of c-MAF have been observed in human MM. Although c-MAF might function as an oncogene in human MM, there has been no report thus far describing the direct induction of MM by c-MAF overexpression in vivo. In this study, we have generated transgenic (TG) mice that express c-Maf specifically in the B-cell compartment. Aged c-Maf TG mice developed B-cell lymphomas with some clinical features that resembled those of MM, namely, plasma cell expansion and hyperglobulinemia. Quantitative RT-PCR analysis demonstrated that Ccnd2 and Itgb7, which are known target genes of c-Maf, were highly expressed in the lymphoma cells. This novel TG mouse model of the human MM t(14;16)(q32;q23) chromosomal translocation should serve to provide new insight into the role of c-MAF in tumorigenesis. |
| URI: | http://hdl.handle.net/2241/117284 |
| Rights: | © 2011 American Association for Cancer Research |
| Text Version: | author |
| Appears in Collections: | 森戸 直記 (Morito Naoki)
楊 景堯 (Yoh Keigyou)
工藤 崇 (Kudo Takashi)
山縣 憲司 (Yamagata Kenji)
高橋 智 (Takahashi Satoru)
Cancer research
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