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Journal of experimental medicine >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/107854
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| Title: | The innate immune system in host mice targets cells with allogenic mitochondrial DNA |
| Authors: | Ishikawa, Kaori
Toyama-Sorimachi, Noriko
Nakada, Kazuto
Morimoto, Mami
Imanishi, Hirotake
Yoshizaki, Mariko
Sasawatari, Shigemi
Niikura, Mamoru
Takenaga, Keizo
Yonekawa, Hiromichi
Hayashi, Jun-Ichi
中田, 和人
林, 純一 |
| Issue Date: | Oct-2010 |
| Publisher: | The Rockefeller University Press |
| Journal Title: | Journal of experimental medicine |
| Volume: | 207 |
| Issue: | 11 |
| Start Page: | 2297 |
| End Page: | 2305 |
| DOI: | 10.1084/jem.20092296 |
| PMID: | 20937705 |
| Abstract: | Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various disorders, but the effects of mtDNA imported into transplants from different individuals or aged subjects have been unclear. We examined this issue by generating trans-mitochondrial tumor cells and embryonic stem cells that shared the syngenic C57BL/6 (B6) strain–derived nuclear DNA background but possessed mtDNA derived from allogenic mouse strains. We demonstrate that transplants with mtDNA from the NZB/B1NJ strain were rejected from the host B6 mice, not by the acquired immune system but by the innate immune system. This rejection was caused partly by NK cells and involved a MyD88-dependent pathway. These results introduce novel roles of mtDNA and innate immunity in tumor immunology and transplantation medicine. |
| URI: | http://hdl.handle.net/2241/107854 |
| Rights: | © 2010 Ishikawa et al. |
| Text Version: | publisher |
| Appears in Collections: | 中田 和人 (Nakada Kazuto)
林 純一 (Hayashi Jun-Ichi)
Journal of experimental medicine
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