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つくばリポジトリ (Tulips-R) >
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Journal of biomedicine and biotechnology >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/106013
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| Title: | Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population |
| Authors: | Kawasaki, Aya
Ito, Ikue
Ito, Satoshi
Hayashi, Taichi
Goto, Daisuke
Matsumoto, Isao
Takasaki, Yoshinari
Hashimoto, Hiroshi
Sumida, Takayuki
Tsuchiya, Naoyuki
林, 太智
松本, 功
住田, 孝之
土屋, 尚之 |
| Issue Date: | 2010 |
| Publisher: | Hindawi Publishing |
| Journal Title: | Journal of biomedicine and biotechnology |
| Volume: | 2010 |
| Start Page: | 207578 |
| DOI: | 10.1155/2010/207578 |
| PMID: | 20617138 |
| Abstract: | Recent genome-wide association studies demonstrated association of single nucleotide polymorphisms (SNPs) in the TNFAIP3 region at 6q23 with systemic lupus erythematosus (SLE) in European-American populations. In this study, we investigated whether SNPs in the TNFAIP3 region are associated with SLE also in a Japanese population. A case-control association study was performed on the SNPs rs13192841, rs2230926, and rs6922466 in 318 Japanese SLE patients and 444 healthy controls. Association of rs2230926 G allele with SLE was replicated in Japanese (allelic association P=.033, odds ratio [OR] 1.47, recessive model P=.023, OR 8.52). The association was preferentially observed in the SLE patients with nephritis. When the TNFAIP3 mRNA levels of the HapMap samples were examined using GENEVAR database, the presence of TNFAIP3 rs2230926 G allele was associated with lower mRNA expression of TNFAIP3 (P=.013). These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations. |
| URI: | http://hdl.handle.net/2241/106013 |
| Rights: | © 2010 Aya Kawasaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Text Version: | author |
| Appears in Collections: | 林 太智 (Hayashi Taichi)
松本 功 (Matsumoto Isao)
住田 孝之 (Sumida Takayuki)
土屋 尚之 (Tsuchiya Naoyuki)
Journal of biomedicine and biotechnology
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