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つくばリポジトリ (Tulips-R) >
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Immunity >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/102003
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| Title: | Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule |
| Authors: | Shibuya, Kazuko
Lanier, Lewis L.
Phillips, Joseph H.
Ochs, Hans D.
Shimizu, Kenji
Nakayama, Eiichi
Nakauchi, Hiromitsu
Shibuya, Akira
渋谷, 彰
渋谷, 和子 |
| Issue Date: | Nov-1999 |
| Publisher: | Cell Press |
| Journal Title: | Immunity |
| Volume: | 11 |
| Issue: | 5 |
| Start Page: | 615 |
| End Page: | 623 |
| DOI: | 10.1016/S1074-7613(00)80136-3 |
| PMID: | 10591186 |
| Abstract: | Whereas ligation of the DNAM-1 adhesion molecule triggers cytotoxicity mediated by normal NK and T cells, this function was defective in NK cell clones from leukocyte adhesion deficiency syndrome. However, genetic reconstitution of cell surface expression of LFA-1 restored the ability of DNAM-1 to initiate anti-DNAM-1 mAb-induced cytotoxicity, indicating a functional relationship between DNAM-1 and LFA-1. Further studies demonstrated that LFA-1 physically associates with DNAM-1 in NK cells and anti-CD3 mAb stimulated T cells, for which serine phosphorylation of DNAM-1 plays a critical role. In addition, crosslinking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals. |
| URI: | http://hdl.handle.net/2241/102003 |
| Rights: | (c) 1999 by Cell Press |
| Text Version: | author |
| Appears in Collections: | Immunity
渋谷 彰 (Shibuya Akira)
渋谷 和子 (Shibuya Kazuko)
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