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|Title: ||Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule|
|Authors: ||Shibuya, Kazuko|
Lanier, Lewis L.
Phillips, Joseph H.
Ochs, Hans D.
|Issue Date: ||Nov-1999 |
|Publisher: ||Cell Press|
|Journal Title: ||Immunity|
|Start Page: ||615|
|End Page: ||623|
|Abstract: ||Whereas ligation of the DNAM-1 adhesion molecule triggers cytotoxicity mediated by normal NK and T cells, this function was defective in NK cell clones from leukocyte adhesion deficiency syndrome. However, genetic reconstitution of cell surface expression of LFA-1 restored the ability of DNAM-1 to initiate anti-DNAM-1 mAb-induced cytotoxicity, indicating a functional relationship between DNAM-1 and LFA-1. Further studies demonstrated that LFA-1 physically associates with DNAM-1 in NK cells and anti-CD3 mAb stimulated T cells, for which serine phosphorylation of DNAM-1 plays a critical role. In addition, crosslinking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals.|
|Rights: ||(c) 1999 by Cell Press|
|Text Version: ||author|
|Appears in Collections:||Immunity|
渋谷 彰 (Shibuya Akira)
渋谷 和子 (Shibuya Kazuko)
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