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つくばリポジトリ (Tulips-R) >
0 コンテンツタイプ別 (Content type) >
01 雑誌発表論文等 (Journal article, etc.) >
Journal of experimental medicine >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/101756
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| Title: | Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation |
| Authors: | Yotsumoto, Katsumi
Okoshi, Yasushi
Shibuya, Kazuko
Yamazaki, Satoshi
Tahara-Hanaoka, Satoko
Honda, Shin-ichiro
Osawa, Mitsujiro
Kuroiwa, Asato
Matsuda, Yoichi
Tenen, Daniel G.
Iwama, Atsushi
Nakauchi, Hiromitsu
Shibuya, Akira
大越, 靖
渋谷, 和子
田原, 聡子
本多, 伸一郎
渋谷, 彰 |
| Issue Date: | Jul-2003 |
| Publisher: | Rockefeller University Press |
| Journal Title: | Journal of experimental medicine |
| Volume: | 198 |
| Issue: | 2 |
| Start Page: | 223 |
| End Page: | 233 |
| DOI: | 10.1084/jem.20021825 |
| PMID: | 12874256 |
| Abstract: | Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domain and mediates endocytosis of the receptor and inhibition of IgE-mediated degranulation from mast cells. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12 and stimulates proinflammatory cytokines and chemokine secretions from macrophages. Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses. |
| URI: | http://hdl.handle.net/2241/101756 |
| Rights: | ©Rockefeller University Press |
| Text Version: | publisher |
| Appears in Collections: | 渋谷 彰 (Shibuya Akira)
渋谷 和子 (Shibuya Kazuko)
Journal of experimental medicine
田原 聡子 (Tahara Satoko)
大越 靖 (Okoshi Yasushi)
本多 伸一郎 (Honda Shin-ichiro)
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