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つくばリポジトリ (Tulips-R) >
0 コンテンツタイプ別 (Content type) >
01 雑誌発表論文等 (Journal article, etc.) >
Hypertension research >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2241/100059
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| Title: | Arterial Stiffness, Physical Activity, and Atrial Natriuretic Peptide Gene Polymorphism in Older Subjects |
| Authors: | IEMITSU, Motoyuki
MAEDA, Seiji
OTSUKI, Takeshi
SUGAWARA, Jun
KUNO, Shinya
AJISAKA, Ryuichi
MATSUDA, Mitsuo
前田, 清司
久野, 譜也
鰺坂, 隆一 |
| Issue Date: | Apr-2008 |
| Publisher: | the Japanese Society of Hypertension |
| Journal Title: | Hypertension research |
| Volume: | 31 |
| Issue: | 4 |
| Start Page: | 767 |
| End Page: | 774 |
| DOI: | 10.1291/hypres.31.767 |
| PMID: | 18633189 |
| Abstract: | An increase in arterial stiffness with advancing age is associated with several pathological states, including
hypertension and arteriosclerosis. Regular exercise improves the aging-induced increase in arterial stiffness
and has a protective effect against these diseases. However, not all individuals respond to exercise
to the same extent. Atrial natriuretic peptide (ANP) is involved in the regulation of basal blood pressure,
blood flow, and vascular tone. The present study was designed to clarify whether gene polymorphisms in
ANP-related genes affect exercise-induced improvements in arterial stiffness. We performed a cross-sectional
study of 291 healthy middle-aged and older Japanese subjects (63±1 years), examining the relationship
between daily physical activity–induced improvements in arterial stiffness, estimated by brachial-ankle
arterial pulse wave velocity (baPWV), and the gene polymorphisms of valine32methionine (V32M: 664G>A)
in exon 1 of ANP and asparagine521aspartic acid (N521D: 1780A>G) in exon 8 of the ANP clearance receptor
(NPR-C). The baseline baPWV was significantly lower in the active group, but no differences were seen in
blood pressure. Active subjects with the ANP-VV genotype had significantly lower baPWV and higher
plasma ANP levels compared with inactive subjects, but there were no variations related to the VM+MM
genotype. Additionally, baPWV and plasma ANP levels were negatively correlated in ANP-VV genotype
subjects, but were not correlated in VM+MM individuals. Our results suggest that ANP polymorphism
in older Japanese subjects may affect the cardiovascular response to regular exercise. |
| URI: | http://hdl.handle.net/2241/100059 |
| Rights: | ©2008 by the Japanese Society of Hypertension |
| Text Version: | publisher |
| Appears in Collections: | Hypertension research
前田 清司 (Maeda Seiji)
鰺坂 隆一 (Ajisaka Ryuichi)
久野 譜也 (Kuno Shinya)
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